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Rutin-Increased antioxidant activity and skin penetration by nanocrystal technology (smartCrystals)

Cosmetics, ISSN: 2079-9284, Vol: 3, Issue: 1
2016
  • 53
    Citations
  • 0
    Usage
  • 91
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    53
    • Citation Indexes
      53
  • Captures
    91

Article Description

Rutin is a well-known antioxidant from the group of flavonoids. Its use in cosmetic dermal products is, however, limited due to its poor water solubility. In order to increase rutin saturation solubility and improve the diffusion to the skin, rutin nanocrystals were produced by the smartCrystal process, e.g., bead milling followed by high pressure homogenization. Rutin nanocrystals were further incorporated into hydroxypropyl cellulose (HPC) gel and its long-term stability was assessed. Determination of the antioxidant activity was made by the DPPH (2,2-diphenyl-1-picrylhydrazyl) assay for these formulations: rutin nanocrystals (mean size 300 nm), rutin raw drug powder (mean size 33 μm) and commercial product. Furthermore, the skin penetration profile of rutin was investigated by the tape-stripping method on porcine skin. This study demonstrated that rutin nanocrystal gel had the highest neutralizing activity (90%), followed by a commercial product and rutin raw drug powder. According to the skin study, rutin nanocrystals penetrated to the deeper layers of the stratum corneum, the horny layer of the skin.

Bibliographic Details

Sung Min Pyo; Rainer H. Müller; Martina Meinke; Cornelia M. Keck

MDPI AG

Medicine; Chemical Engineering; Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics

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