Local Treatment Efficacy for Single-Area Squamous Cell Carcinoma of the Unknown Primary Site
Current Oncology, ISSN: 1718-7729, Vol: 30, Issue: 10, Page: 9327-9334
2023
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Most Recent News
Studies from University of Occupational and Environmental Health Provide New Data on Squamous Cell Carcinoma (Local Treatment Efficacy for Single-Area Squamous Cell Carcinoma of the Unknown Primary Site)
2023 NOV 03 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx Drug Daily -- New research on squamous cell carcinoma is the subject
Article Description
The prognosis for cancer of unknown primary site (CUP) is poor, and squamous cell carcinoma of the unknown primary site (SCCUP) is a rare histological type. CUP is often treated with aggressive multimodal treatments, while the treatment of single-area localized CUP remains controversial. We retrospectively reviewed the medical records of patients with CUP. SCCUP in women was classified according to several definitions. Based on the histologic type and site, they were classified into favorable and unfavorable subsets. We further divided SCCUP into two types (single and multiple areas) and reviewed treatment and efficacy. Among the 227 female CUP patients, 36 (15%) had SCCUP. The median age was 59.9 years (range, 31–90 years). Most patients (61.1%) had a good performance status. Of the SCCUP patients, 22 had cancer in a single area, and 14 in multiple areas. Single-area SCCUP was further divided into favorable (16 cases) and unfavorable subsets (6 cases). In the favorable subset, local treatment was predominant, and almost all cases had a good prognosis. Even in the unfavorable subset, local therapy was combined with systemic chemotherapy in only two cases, and four cases showed no recurrences. Local treatment may be effective for single-area SCCUP, even in the unfavorable subset.
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MDPI AG
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