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Acute generalized exanthematous pustulosis: Pathogenesis, genetic background, clinical variants and therapy

International Journal of Molecular Sciences, ISSN: 1422-0067, Vol: 17, Issue: 8, Page: 1214
2016
  • 144
    Citations
  • 0
    Usage
  • 194
    Captures
  • 8
    Mentions
  • 150
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    144
  • Captures
    194
  • Mentions
    8
    • References
      6
      • Wikipedia
        6
    • News Mentions
      2
      • News
        2
  • Social Media
    150
    • Shares, Likes & Comments
      150
      • Facebook
        150

Most Recent News

AGEP Following a New Weight Loss Regimen

A 55-Year-Old Man with Erythematous Papules Following a New Weight Loss Regimen A 55-year-old obese African American male presented with a two-month history of erythematous

Review Description

Acute generalized exanthematous pustulosis (AGEP) is a severe, usually drug-related reaction, characterized by an acute onset of mainly small non-follicular pustules on an erythematous base and spontaneous resolution usually within two weeks. Systemic involvement occurs in about 20% of cases. The course is mostly benign, and only in rare cases complications lead to life-threatening situations. Recent studies highlight the importance of genetic variations in interleukin-36 receptor antagonist gene (IL-36RN) in the pathogenesis of this disease. The physiopathology of AGEP remains unclear, but an involvement of innate and acquired immune cells together with resident cells (keratinocytes), which recruit and activate neutrophils via production of cytokines/chemokines such as IL-17, IL-36, granulocyte-macrophage colony-stimulating factor (GM-CSF), tumor necrosis factor alpha (TNFα) and chemokine (C-X-C motif) ligand 8 (CXCL8)/IL-8, has been postulated. Treatment is based on the removal of the causative drug, supportive care, infection prevention and use of potent topical or systemic steroids.

Bibliographic Details

Feldmeyer, Laurence; Heidemeyer, Kristine; Yawalkar, Nikhil

MDPI AG

Chemical Engineering; Biochemistry, Genetics and Molecular Biology; Chemistry; Computer Science

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