Translationally controlled tumor protein stimulates dopamine release from PC12 cells via Ca-independent phospholipase A pathways
International Journal of Molecular Sciences, ISSN: 1422-0067, Vol: 17, Issue: 10, Page: 1774
2016
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Article Description
The translationally controlled tumor protein (TCTP), initially identified as a tumor- and growth-related protein, is also known as a histamine-releasing factor (HRF). TCTP is widely distributed in the neuronal systems, but its function is largely uncharacterized. Here, we report a novel function of TCTP in the neurotransmitter release from a neurosecretory, pheochromocytoma (PC12) cells. Treatment with recombinant TCTP (rTCTP) enhanced both basal and depolarization (50 mM KCl)-evoked [H]dopamine release in concentration- and time-dependent manners. Interestingly, even though rTCTP induced the increase in intracellular calcium levels ([Ca]), the rTCTP-driven effect on dopamine release was mediated by a Ca-independent pathway, as evidenced by the fact that Ca-modulating agents such as Ca chelators and a voltage-gated L-type Ca-channel blocker did not produce any changes in rTCTP-evoked dopamine release. In a study to investigate the involvement of phospholipase A (PLA) in rTCTP-induced dopamine release, the inhibitor for Ca-independent PLA (iPLA) produced a significant inhibitory effect on rTCTP-induced dopamine release, whereas this release was not significantly inhibited by Ca-dependent cytosolic PLA (cPLA) and secretory PLA (sPLA) inhibitors. We found that rTCTP-induced dopamine release from neuronal PC12 cells was modulated by a Ca-independent mechanism that involved PLA in the process, suggesting the regulatory role of TCTP in the neuronal functions.
Bibliographic Details
MDPI AG
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