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Chemopreventive strategies for inflammation-related carcinogenesis: Current status and future direction

International Journal of Molecular Sciences, ISSN: 1422-0067, Vol: 18, Issue: 4
2017
  • 26
    Citations
  • 0
    Usage
  • 76
    Captures
  • 0
    Mentions
  • 32
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    26
  • Captures
    76
  • Social Media
    32
    • Shares, Likes & Comments
      32
      • Facebook
        32

Review Description

A sustained and chronically-inflamed environment is characterized by the presence of heterogeneous inflammatory cellular components, including neutrophils, macrophages, lymphocytes and fibroblasts. These infiltrated cells produce growth stimulating mediators (inflammatory cytokines and growth factors), chemotactic factors (chemokines) and genotoxic substances (reactive oxygen species and nitrogen oxide) and induce DNA damage and methylation. Therefore, chronic inflammation serves as an intrinsic niche for carcinogenesis and tumor progression. In this article, we summarize the up-to-date findings regarding definitive/possible causes and mechanisms of inflammation-related carcinogenesis derived from experimental and clinical studies. We also propose 10 strategies, as well as candidate agents for the prevention of inflammation-related carcinogenesis.

Bibliographic Details

Kanda, Yusuke; Osaki, Mitsuhiko; Okada, Futoshi

MDPI AG

Chemical Engineering; Biochemistry, Genetics and Molecular Biology; Chemistry; Computer Science

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