mir-206-3p inhibits 3T3-L1 cell adipogenesis via the c-Met/Pi3k/Akt pathway
International Journal of Molecular Sciences, ISSN: 1422-0067, Vol: 18, Issue: 7
2017
- 38Citations
- 30Captures
- 1Mentions
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- Citations38
- Citation Indexes38
- 38
- CrossRef32
- Captures30
- Readers30
- 30
- Mentions1
- Blog Mentions1
- Blog1
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IJMS, Vol. 18, Pages 1510: miR-206-3p Inhibits 3T3-L1 Cell Adipogenesis via the c-Met/PI3K/Akt Pathway
Volume 18, Issue 7 ► ▼ Article Menu Article Versions Abstract Full-Text PDF [3940 KB] Full-Text HTML Full-Text XML Article Versions Notes Related Info Google
Article Description
MicroRNAs (miRNAs) are important post-transcriptional regulators during adipocyte adipogenesis. MiR-206-3p, a tissue-specific miRNA, is absent in white adipocytes. In this study, we examined the roles of mmu-miR-206-3p in the adipogenic differentiation of 3T3-L1 preadipocytes. The miR-206-3p expression has shown an apparent decreasing trend after induction, and sustained low expression throughout the differentiation of 3T3-L1 cells. miR-206-3p blocked the adipogenic differentiation of 3T3-L1 cells by attenuating c-Met expression; the inhibition effect of miR-206 to the adipogenic differentiation can be counteracted by restoring c-Met expression. In addition, miR-206-3p decreased the phosphorylation of Akt, which is the downstream effector of c-Met in the PI3K/Akt signaling pathway. These data indicate that miR-206-3p inhibits adipocyte adipogenesis through silencing c-Met and subsequently inactivating the PI3K/Akt signaling pathway.
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