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Age-related loss of cohesion: Causes and effects

International Journal of Molecular Sciences, ISSN: 1422-0067, Vol: 18, Issue: 7
2017
  • 37
    Citations
  • 0
    Usage
  • 97
    Captures
  • 4
    Mentions
  • 14
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    37
  • Captures
    97
  • Mentions
    4
    • Blog Mentions
      2
      • 2
    • References
      2
      • 2
  • Social Media
    14
    • Shares, Likes & Comments
      14
      • Facebook
        14

Most Recent Blog

Reviewing the Aging of the Ovaries

The ovaries , like the thymus , undergo a form of degenerative aging that occurs somewhat in advance of the aging of other parts of

Review Description

Aneuploidy is a leading genetic cause of birth defects and lower implantation rates in humans. Most errors in chromosome number originate from oocytes. Aneuploidy in oocytes increases with advanced maternal age. Recent studies support the hypothesis that cohesion deterioration with advanced maternal age represents a leading cause of age-related aneuploidy. Cohesin generates cohesion, and is established only during the premeiotic S phase of fetal development without any replenishment throughout a female’s period of fertility. Cohesion holds sister chromatids together until meiosis resumes at puberty, and then chromosome segregation requires the release of sister chromatid cohesion from chromosome arms and centromeres at anaphase I and anaphase II, respectively. The time of cohesion cleavage plays an important role in correct chromosome segregation. This review focuses specifically on the causes and effects of age-related cohesion deterioration in female meiosis.

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