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Connexins: Synthesis, post-translational modifications, and trafficking in health and disease

International Journal of Molecular Sciences, ISSN: 1422-0067, Vol: 19, Issue: 5
2018
  • 96
    Citations
  • 0
    Usage
  • 126
    Captures
  • 0
    Mentions
  • 25
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    96
  • Captures
    126
  • Social Media
    25
    • Shares, Likes & Comments
      25
      • Facebook
        25

Review Description

Connexins are tetraspan transmembrane proteins that form gap junctions and facilitate direct intercellular communication, a critical feature for the development, function, and homeostasis of tissues and organs. In addition, a growing number of gap junction-independent functions are being ascribed to these proteins. The connexin gene family is under extensive regulation at the transcriptional and post-transcriptional level, and undergoes numerous modifications at the protein level, including phosphorylation, which ultimately affects their trafficking, stability, and function. Here, we summarize these key regulatory events, with emphasis on how these affect connexin multifunctionality in health and disease.

Bibliographic Details

Aasen, Trond; Johnstone, Scott; Vidal-Brime, Laia; Lynn, K Sabrina; Koval, Michael

MDPI AG

Chemical Engineering; Biochemistry, Genetics and Molecular Biology; Chemistry; Computer Science

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