Synthesis of new quinoline-piperonal hybrids as potential drugs against Alzheimer’s disease
International Journal of Molecular Sciences, ISSN: 1422-0067, Vol: 20, Issue: 16
2019
- 23Citations
- 37Captures
- 1Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations23
- Citation Indexes23
- CrossRef23
- 21
- Captures37
- Readers37
- 37
- Mentions1
- News Mentions1
- News1
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Synthesis of New Quinoline-Piperonal Hybrids as Potential Drugs against Alzheimer's Disease.
Int J Mol Sci. 2019 Aug 14;20(16) Authors: de Oliveira C Brum J, Neto DC, de Almeida JS, Lima JA, Kuca K, França TC, Figueroa-Villar JD PubMed: 31416113 Submit Comment
Article Description
Six quinoline-piperonal hybrids were synthesized and evaluated as potential drugs against Alzheimer’s disease (AD). Theoretical analysis of the pharmacokinetic and toxicological properties of the compounds suggest that they present good oral bio-availability and are also capable of penetrating the blood–brain barrier, qualifying as leads for new drugs against AD. Evaluation of their inhibitory capacity against acetyl-and butyrilcholinesterases (AChE and BChE) through Ellmann’s test showed that three compounds present promising results with one of them being capable of inhibiting both enzymes. Further docking studies of the six compounds synthesized helped to elucidate the main interactions that may be responsible for the inhibitory activities observed.
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