Conformation and domain movement analysis of human matrix metalloproteinase-2: Role of associated Zn and Ca ions
International Journal of Molecular Sciences, ISSN: 1422-0067, Vol: 20, Issue: 17
2019
- 7Citations
- 27Captures
- 1Mentions
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations7
- Citation Indexes7
- CrossRef5
- Captures27
- Readers27
- 27
- Mentions1
- News Mentions1
- 1
Most Recent News
Alterations of mRNA and IncRNA profiles associated with the extracellular matrix and spermatogenesis in goats.
INTRODUCTION Mammalian testicular development and spermatogenesis are complex processes regulated by the transcriptome; they are dynamic and staged [1]. Testis-specific genes play a crucial role
Article Description
Matrix metaloproteinase-2 (MMP-2) is an extracellular Zn protease specific to type I and IV collagens. Its expression is associated with several inflammatory, degenerative, and malignant diseases. Conformational properties, domain movements, and interactions between MMP-2 and its associated metal ions were characterized using a 1.0 µs molecular dynamics simulation. Dihedral principle component analysis revealed ten families of conformations with the greatest degree of variability occurring in the link region connecting the catalytic and hemopexin domains. Dynamic cross-correlation analysis indicated domain movements corresponding to the opening and closing of the hemopexin domain in relation to the fibronectin and catalytic domains facilitated by the link region. Interaction energies were calculated using the molecular mechanics Poisson Boltzman surface area-interaction entropy (MMPBSA-IE) analysis method and revealed strong binding energies for the catalytic Zn ion 1, Ca ion 1, and Ca ion 3 with significant conformational stability at the binding sites of Zn ion 1 and Ca ion 1. Ca ion 2 diffuses freely away from its crystallographically defined binding site. Zn ion 2 plays a minor role in conformational stability of the catalytic domain while Ca ion 3 is strongly attracted to the highly electronegative sidechains of the Asp residues around the central β-sheet core of the hemopexin domain; however, the interacting residue sidechain carboxyl groups are outside of Ca ion 3s coordination sphere.
Bibliographic Details
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know