PlumX Metrics
Embed PlumX Metrics

Autoimmune Neuroinflammatory Diseases: Role of Interleukins

International Journal of Molecular Sciences, ISSN: 1422-0067, Vol: 24, Issue: 9
2023
  • 14
    Citations
  • 0
    Usage
  • 59
    Captures
  • 3
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Most Recent News

Mendelian Randomization Analysis of Circulating Cytokines and Risk of Autoimmune Neuroinflammatory Diseases

Introduction Autoimmune neuroinflammatory diseases (ANDs) are a type of diseases characterized with the mistaken attack on its own nervous system by the immune system, leading

Review Description

Autoimmune neuroinflammatory diseases are a group of disorders resulting from abnormal immune responses in the nervous system, causing inflammation and tissue damage. The interleukin (IL) family of cytokines, especially IL-1, IL-6, and IL-17, plays a critical role in the pathogenesis of these diseases. IL-1 is involved in the activation of immune cells, production of pro-inflammatory cytokines, and promotion of blood-brain barrier breakdown. IL-6 is essential for the differentiation of T cells into Th17 cells and has been implicated in the initiation and progression of neuroinflammation. IL-17 is a potent pro-inflammatory cytokine produced by Th17 cells that plays a crucial role in recruiting immune cells to sites of inflammation. This review summarizes the current understanding of the roles of different interleukins in autoimmune neuroinflammatory diseases, including multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer’s disease, neuromyelitis optica, and autoimmune encephalitis, and discusses the potential of targeting ILs as a therapeutic strategy against these diseases. We also highlight the need for further research to better understand the roles of ILs in autoimmune neuroinflammatory diseases and to identify new targets for treating these debilitating diseases.

Bibliographic Details

Khan, Abdul Waheed; Farooq, Mariya; Hwang, Moon-Jung; Haseeb, Muhammad; Choi, Sangdun

MDPI AG

Chemical Engineering; Biochemistry, Genetics and Molecular Biology; Chemistry; Computer Science

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know