PlumX Metrics
Embed PlumX Metrics

Therapeutic Effects of Perilla Phenols in Oral Squamous Cell Carcinoma

International Journal of Molecular Sciences, ISSN: 1422-0067, Vol: 24, Issue: 19
2023
  • 1
    Citations
  • 0
    Usage
  • 3
    Captures
  • 2
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Most Recent News

National Institute of Cancer Research Researcher Adds New Study Findings to Research in Oral Squamous Cell Carcinoma (Therapeutic Effects of Perilla Phenols in Oral Squamous Cell Carcinoma)

2023 OCT 25 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx Drug Daily -- Current study results on oral squamous cell carcinoma have

Article Description

The herbal medicine perilla leaf extract (PLE) exhibits various pharmacological properties. We showed that PLE inhibits the viability of oral squamous cell carcinoma (OSCC) cells. HPLC analysis revealed that caffeic acid (CA) and rosmarinic acid (RA) are the two main phenols in PLE, and reduced OSCC cell viability in a dose-dependent manner. The optimal CA/RA combination ratio was 1:2 at concentrations of 300–500 μM but had no synergistic inhibitory effect on the viability of OSCC cells. CA, RA, or their combination effectively suppressed interleukin (IL)-1β secretion by OSCC OC3 cells. Long-term treatment with CA and CA/RA mixtures, respectively, induced EGFR activation, which might cause OC3 cells to become EGFR-dependent and consequently increased the sensitivity of OC3 cells to a low dose (5 μM) of the EGFR tyrosine kinase inhibitor gefitinib. Chronic treatment with CA, RA, or their combination exhibited an inhibitory effect more potent than that of low-dose (1 μM) cisplatin on the colony formation ability of OSCC cells; this may be attributed to the induction of apoptosis by these treatments. These findings suggest that perilla phenols, particularly CA and RA, can be used as adjuvant therapies to improve the efficacy of chemotherapy and EGFR-targeted therapy in OSCC.

Bibliographic Details

Lee, Chia-Huei; Tsao, Yu-Hsin; Weng, Yui-Ping; Wang, I-Ching; Chen, Yao-Ping; Hung, Pin-Feng

MDPI AG

Chemical Engineering; Biochemistry, Genetics and Molecular Biology; Chemistry; Computer Science

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know