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Neuromuscular Electrical Stimulation during Hemodialysis Suppresses Postprandial Hyperglycemia in Patients with End-Stage Diabetic Kidney Disease: A Crossover Controlled Trial

Journal of Clinical Medicine, ISSN: 2077-0383, Vol: 11, Issue: 21
2022
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New Hyperglycemia Study Findings Have Been Reported by Researchers at Dokkyo Medical University Nikko Medical Center (Neuromuscular Electrical Stimulation during Hemodialysis Suppresses Postprandial Hyperglycemia in Patients with End-Stage ...)

2022 NOV 28 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Trials Daily -- Investigators publish new report on hyperglycemia. According to news

Article Description

Hemodialysis patients with diabetic kidney disease (DKD) experience blood glucose fluctuations owing to insulin removal. We evaluated the effects of single and long-term application of neuromuscular electrical stimulation (NMES) during hemodialysis on glycemic control. This trial was conducted in two stages: Stage 1, following a crossover design and 4 week washout period, eleven outpatients with DKD either underwent a single bout of NMES for 30 min (NMES period) or rested (control period) after receiving nutritional support during hemodialysis; Stage 2, following a crossover design and 4 week washout period, each participant received the intervention for 12 weeks. NMES was administered for 30 min at the maximum tolerable intensity. The mean subcutaneous glucose concentration and mean amplitude of glycemic excursion (MAGE) were determined by flash glucose monitoring for 24 h. Changes in glycoalbumin and MAGE before and after NMES initiation were evaluated. The mean blood glucose level and MAGE after a single bout of NMES were significantly lower than those after rest. Glycoalbumin levels and echo intensity of the rectus femoris tended to decrease, but not significantly by ANOVA due to a lack in statistical power after the dropout of three patients. NMES in end-stage DKD decreased blood glucose levels during and after hemodialysis.

Bibliographic Details

Tsurumi, Tomoki; Tamura, Yuma; Nakatani, Yuki; Furuya, Tomoki; Tamiya, Hajime; Terashima, Masato; Tomoe, Takashi; Ueno, Asuka; Shimoyama, Masahiro; Yasu, Takanori

MDPI AG

Medicine

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