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Autoantibodies against protein phosphatase magnesium-dependent 1a as a biomarker for predicting radiographic progression in ankylosing spondylitis treated with anti-tumor necrosis factor agents

Journal of Clinical Medicine, ISSN: 2077-0383, Vol: 9, Issue: 12, Page: 1-11
2020
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Article Description

Background: Patients with ankylosing spondylitis (AS) have increased levels of protein phosphatase magnesium-dependent 1A (PPM1A) and autoantibodies. We evaluated the usefulness of serum anti-PPM1A antibodies as a biomarker for AS. Methods: Serum samples from 58 AS patients were obtained from a multicenter registry prior to the initiation of anti-TNF agents. The serum levels of anti-PPM1A antibodies were measured using ELISA. Spinal radiographic progression was defined as an increase in the modified stoke ankylosing spondylitis spinal score (mSASSS) by ≥2 units or a newly developed syndesmophyte. The role of exogenous PPM1A on bone mineralization was evaluated using primary osteoprogenitors acquired from patients with AS and non-inflammatory controls. Results: The baseline levels of anti-PPM1A antibodies and mSASSS were higher in the radiographic progression group than in the non-progression group. In logistic regression analysis, baseline mSASSS and serum anti-PPM1A antibodies were associated with a higher risk of progression. The level of anti-PPM1A antibodies for predicting progression had an AUC of 0.716 (cut-off value: 43.77 ng/mL). PPM1A stimulation increased matrix mineralization in AS-osteoprogenitors but not in controls. Conclusion: Along with mSASSS, the serum levels of anti-PPM1A antibodies might be useful as a predictor of radiographic progression after treatment with anti-TNF agents.

Bibliographic Details

Lee, Jung-Sun; Lee, Eun-Ju; Lee, Jae-Hyun; Hong, Seok-Chan; Lee, Chang-Keun; Yoo, Bin; Oh, Ji-Seon; Lee, Sang-Hoon; Kim, Tae-Jong; Lee, Seung-Hun; Jo, Sung-Sin; Yoo, Dae-Hyun; Park, Ye-Soo; Kim, Tae-Hwan; Kim, Yong-Gil

MDPI AG

Medicine

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