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Neurosteroids in Glioma: A Novel Therapeutic Concept

Life, ISSN: 2075-1729, Vol: 14, Issue: 8
2024
  • 1
    Citations
  • 0
    Usage
  • 2
    Captures
  • 1
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    1
  • Captures
    2
  • Mentions
    1
    • News Mentions
      1
      • News
        1

Most Recent News

Recent Findings in Gliomas Described by a Researcher from University of Virginia (Neurosteroids in Glioma: A Novel Therapeutic Concept)

2024 AUG 15 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Oncology Daily -- Current study results on gliomas have been published. According

Review Description

Glioma, a diverse group of brain and spinal cord tumors arising from glial cells, is characterized by varying degrees of malignancy, with some types exhibiting highly aggressive behavior, rapid proliferation, and invasive growth patterns, posing significant therapeutic challenges. This review delves into the complex interactions between glioma cells, neurotransmitters, and neurosteroids, emphasizing their potential as therapeutic targets. Key neurotransmitters, like glutamate and gamma-aminobutyric acid (GABA), play crucial roles in glioma growth, invasion, and treatment response. This review examines the involvement of neurosteroids in glioma biology and explores innovative therapeutic strategies targeting these systems. It encompasses the biosynthesis and mechanisms of neurosteroids, interactions between gliomas and neurotransmitters, the spatial distribution of neurosteroid synthesis in gliomas, the role of ion channels, hormonal influences, enzyme modulation, and the neuroimmune system in glioma progression. Additionally, it highlights the potential of neurosteroids to modulate these pathways for therapeutic benefit.

Bibliographic Details

Hogan, Ava; Mut, Melike

MDPI AG

Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology; Earth and Planetary Sciences

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