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In Vitro Evaluation of Anti-Hemolytic and Cytotoxic Effects of Traditional Mexican Medicinal Plant Extracts on Human Erythrocytes and Cell Cultures

Life, ISSN: 2075-1729, Vol: 14, Issue: 9
2024
  • 2
    Citations
  • 0
    Usage
  • 8
    Captures
  • 1
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

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  • Citations
    2
  • Captures
    8
  • Mentions
    1
    • News Mentions
      1
      • 1

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Universidad Autonoma de Nuevo Leon Researchers Describe Research in Life Sciences (In Vitro Evaluation of Anti-Hemolytic and Cytotoxic Effects of Traditional Mexican Medicinal Plant Extracts on Human Erythrocytes and Cell Cultures)

2024 OCT 14 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx Life Science Daily -- Current study results on life sciences have been

Article Description

Plant extracts of fifteen plants of ethnomedicinal use in Mexico were analyzed to provide scientific knowledge of their medicinal properties through the evaluation of different biological activities such as anti-hemolytic, antioxidant, and cytotoxic effects in normal cells. Therefore, methanolic extracts were obtained from each of the plants by the Soxhlet extraction. The hemolytic activity in human erythrocytes was evaluated, as was their potential to protect the erythrocyte membrane against the 2,2′-azobis (2-methylpropionamidine) dihydrochloride (AAPH) and 1,1–diphenyl–2–picryl hydrazyl (DPPH) radicals. Finally, the toxicity of the extracts in normal cell cultures of African green monkey kidney cells (Vero) and peripheral blood mononuclear cells (PBMC) was determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction method. Most of the extracts showed low hemolytic activity and high anti-hemolytic activity as well as high selectivity indices (SI) and antioxidant effects. Extracts of H. inuloides, J. dioica, and J. spicigera induced cell proliferation of the Vero cells. K. daigremontiana, A. adstringens, S. mexicanum, J. spicigera, L. tridentata, and M. tenuiflora extracts showed PBMC cell proliferation. In the present study, it was observed that the evaluated extracts did not present hemolytic activity, and some presented low toxicity when Vero and PBMC cell cultures were exposed. In conclusion, traditionally used plants possess beneficial health properties, and it is hoped that this study will serve as a basis for understanding the biological effects of traditionally used plants and may complement future studies.

Bibliographic Details

Elizondo-Luevano, Joel H; Quintanilla-Licea, Ramiro; Castillo-Hernández, Sandra L; Sánchez-García, Eduardo; Bautista-Villarreal, Minerva; González-Meza, Georgia M; Gloria-Garza, Marcela A; Rodríguez-Luis, Osvelia E; Kluz, Maciej Ireneusz; Kačániová, Miroslava

MDPI AG

Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology; Earth and Planetary Sciences

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