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5‐(4‐fluorophenyl)‐3‐(naphthalen‐1‐yl)‐1‐phenyl‐1h‐pyrazole

MolBank, ISSN: 1422-8599, Vol: 2021, Issue: 1
2021
  • 2
    Citations
  • 0
    Usage
  • 3
    Captures
  • 1
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    2
    • Citation Indexes
      2
  • Captures
    3
  • Mentions
    1
    • Blog Mentions
      1
      • Blog
        1

Article Description

A new fluorinated pyrazole, 5‐(4‐fluorophenyl)‐3‐(naphthalen‐1‐yl)‐1‐phenyl‐1H‐pyra-zole was successfully synthesized via a two‐step reaction. Firstly, the synthesis of pyrazoline was performed via one‐pot three‐component reaction under microwave irradiation. Secondly, the synthesis of pyrazole was performed via oxidative aromatization of pyrazoline under conventional heating. The structure of the synthesized compound was confirmed by spectroscopic analysis, in-cluding FT‐IR, HR‐MS, 1D and 2D NMR analysis. Then, molecular docking study showed that the binding affinity of the synthesized compound to human estrogen alpha receptor (ERα) was close to 4‐OHT as a native ligand.

Bibliographic Details

Jasril Jasril; Yuana Nurulita; Adel Zamri; Guntur Guntur; Neni Frimayanti; Ihsan Ikhtiarudin

MDPI AG

Biochemistry, Genetics and Molecular Biology; Chemistry

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