Ibuprofen in a Lipid Bilayer: Nanoscale Spatial Arrangement
Membranes, ISSN: 2077-0375, Vol: 12, Issue: 11
2022
- 9Citations
- 2Captures
- 2Mentions
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Metrics Details
- Citations9
- Citation Indexes9
- CrossRef9
- Captures2
- Readers2
- Mentions2
- Blog Mentions1
- Blog1
- News Mentions1
- News1
Most Recent News
Siberian Branch of the Russian Academy of Sciences (SB RAS) Researchers Update Knowledge of Ibuprofen Therapy (Ibuprofen in a Lipid Bilayer: Nanoscale Spatial Arrangement)
2022 NOV 24 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx Drug Daily -- Data detailed on ibuprofen therapy have been presented. According
Article Description
Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic effects. Understanding the molecular mechanisms of drug interaction with cell membranes is important to improving drug delivery, uptake by cells, possible side effects, etc. Double electron-electron resonance spectroscopy (DEER, also known as PELDOR) provides information on the nanoscale spatial arrangement of spin-labeled molecules. Here, DEER was applied to study (mono-)spin-labeled ibuprofen (ibuprofen-SL) in a bilayer of palmitoyl-oleoyl-sn-glycerophosphocholine (POPC). The results obtained show that the ibuprofen-SL molecules are located within a plane in each bilayer leaflet. At their low molar concentration in the bilayer χ, the found surface concentration of ibuprofen-SL is two times higher than χ, which can be explained by alternative assembling in the two leaflets of the bilayer. When χ > 2 mol%, these assemblies merge. The findings shed new light on the nanoscale spatial arrangement of ibuprofen in biological membranes.
Bibliographic Details
MDPI AG
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