Insights into antibody-mediated alphavirus immunity and vaccine development landscape
Microorganisms, ISSN: 2076-2607, Vol: 9, Issue: 5
2021
- 9Citations
- 29Captures
- 1Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations9
- Citation Indexes9
- CrossRef8
- Captures29
- Readers29
- 29
- Mentions1
- Blog Mentions1
- Blog1
Most Recent Blog
Microorganisms, Vol. 9, Pages 899: Insights into Antibody-Mediated Alphavirus Immunity and Vaccine Development Landscape
Microorganisms, Vol. 9, Pages 899: Insights into Antibody-Mediated Alphavirus Immunity and Vaccine Development Landscape Microorganisms doi: 10.3390/microorganisms9050899 Authors: Anthony Torres-Ruesta Rhonda Sin-Ling Chee Lisa F.
Review Description
Alphaviruses are mosquito-borne pathogens distributed worldwide in tropical and temperate areas causing a wide range of symptoms ranging from inflammatory arthritis-like manifestations to the induction of encephalitis in humans. Historically, large outbreaks in susceptible populations have been recorded followed by the development of protective long-lasting antibody responses suggesting a potential advantageous role for a vaccine. Although the current understanding of alphavirus antibody-mediated immunity has been mainly gathered in natural and experimental settings of chikungunya virus (CHIKV) infection, little is known about the humoral responses triggered by other emerging alphaviruses. This knowledge is needed to improve serology-based diagnostic tests and the development of highly effective cross-protective vaccines. Here, we review the role of antibody-mediated immunity upon arthritogenic and neurotropic alphavirus infections, and the current research efforts for the development of vaccines as a tool to control future alphavirus outbreaks.
Bibliographic Details
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