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Studies with β-oxoalkanonitriles: Simple novel synthesis of 3-[2,6-diaryl-4- pyridyl]-3-oxopropanenitriles

Molecules, ISSN: 1420-3049, Vol: 13, Issue: 12, Page: 3140-3148
2008
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Article Description

Heteroaromatization of ethyl 2-cyano-4-oxo-2-(2-oxo-2-arylethyl)-4- arylbutanoates 3a,b with ammonium acetate gave ethyl 2,6-diarylisonicotinates 4a,b. Treatment of the latter with acetonitrile afforded novel β-oxoalkanonitriles 6a,b. Reactions of 6a,b with phenyl hydrazine and hydroxylamine gave the corresponding pyridyl aminopyrazoles 8a,b and pyridyl aminoisoxazoles 10a,b, respectively. © 2008 by the authors; licensee Molecular Diversity Preservation International.

Bibliographic Details

Sayed M. Riyadh; Hamad M. Al-Matar; Mohamed H. Elnagdi

MDPI AG

Chemistry; Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics

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