PlumX Metrics
Embed PlumX Metrics

General pathway for a convenient one-pot synthesis of trifluoromethyl- containing 2-amino-7-alkyl(aryl/heteroaryl)- 1,8-naphthyridines and fused cycloalkane analogues

Molecules, ISSN: 1420-3049, Vol: 16, Issue: 4, Page: 2817-2832
2011
  • 14
    Citations
  • 0
    Usage
  • 24
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    14
    • Citation Indexes
      14
  • Captures
    24

Article Description

A convenient and general method for the synthesis in 26-73% yields of a new series of 7-alkyl(aryl/heteroaryl)-2-amino-5-trifluoromethyl-1,8-naphthyridines from direct cyclocondensation reactions of 4-alkoxy-1,1,1-trifluoroalk-3-en-2- ones [CFC(O)CH=C(R)OR, where R = H, Me, Ph, 4-MePh, 4-OMePh, 4-FPh, 4-BrPh, 4-NOPh, 2-furyl, 2-thienyl and R = Me, Et] with 2,6-diaminopyridine (2,6-DAP), under mild conditions, is described. Another synthetic route also allowed the synthesis of 2-amino-5- trifluoromethyl-cycloalka[b][1,8]naphthyridines in 33-36% yields, from direct or indirect cyclo-condensation reactions of five-, six- and seven-membered 2-trifluoroacetyl-1-methoxy-cycloalkenes with 2,6-DAP. © 2011 by the authors.

Bibliographic Details

Bonacorso, Helio G; Andrighetto, Rosália; Krüger, Nícolas; Zanatta, Nilo; Martins, Marcos A P

MDPI AG

Chemistry; Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know