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Evaluation of the nano-TiO as a novel deswelling material

Molecules, ISSN: 1420-3049, Vol: 21, Issue: 1, Page: 57
2016
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Article Description

Nano-TiO is widely applied in the automobile exhaust hose reels as a catalyst to reduce oxynitride emissions, including nitric oxide (NO). In the biomedicine field, NO plays an important role in vasodilation and edema formation in human bodies. However, the deswelling activity of nano-TiO has not been reported. Here, we demonstrated that nano-TiO can significantly degrade the production of NO in LPS-induced RAW264.7 mouse macrophages. Further study indicated that nano-TiO exhibited an effect on vascular permeability inhibition, and prevented carrageenan-induced footpad edema. Therefore, we prepared a nano-TiO ointment and observed similar deswelling effects. In conclusion, nano-TiO might act as a novel deswelling agent related with its degradation of NO, which will aid in our ability to design effective interventions for edema involved diseases.

Bibliographic Details

Chu, Ming; Hou, Yue-Long; Xu, Lan; Chu, Zheng-Yun; Zhang, Ming-Bo; Wang, Yue-Dan

MDPI AG

Chemistry; Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics

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