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Hop extract acts as an antioxidant with antimicrobial effects against Propionibacterium acnes and Staphylococcus aureus

Molecules, ISSN: 1420-3049, Vol: 24, Issue: 2
2019
  • 62
    Citations
  • 0
    Usage
  • 163
    Captures
  • 1
    Mentions
  • 3
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    62
  • Captures
    163
  • Mentions
    1
    • News Mentions
      1
      • News
        1
  • Social Media
    3
    • Shares, Likes & Comments
      3
      • Facebook
        3

Most Recent News

19 Amazing Health Benefits Of Hops

Hops are female cone-shaped flowers of the hop plant, Humulus lupulus. The dried flowers are used to treat anxiety, insomnia, tension, nervousness, and many more.

Article Description

Acne is associated with hyperkeratosis, elevated levels of skin sebum and growth of Propionibacterium acnes (P. acnes) and Staphylococcus aureus (S. aureus). Furthermore, P. acnes promotes inflammation by inducing IL-6 production and oxidative stress. The aim of this study was to assess the antioxidant, anti-inflammatory and antibacterial potential of a hop-CO-extract with 50% humulone and lupulone. The susceptibility of P. acnes and S. aureus to the hop extract was tested by using the broth microdilution technique. The minimal inhibitory concentrations (MIC) for P. acnes and S. aureus were 3.1 and 9.4 μg/mL, respectively. In addition, the hop extract showed an antioxidative effect with a half maximal inhibitory concentration (IC) of 29.43 μg/mL as well as additional anti-inflammatory effects by reducing the IL-6 expression (IC: 0.8 μg/mL). In addition, a gel formulation with 0.3% hop extract (w/w) had antibacterial activity against P. acnes and S. aureus (inhibition zone value: 5.5 mm and 3 mm, respectively) which was significantly superior to the placebo gel. The positive control (a gel with the antibiotic clindamycin) showed an inhibition zone of 9 mm. Due to its antioxidant, anti-inflammatory and antibacterial effects hop extract might be a treatment option for acne-prone skin.

Bibliographic Details

Weber, Natalja; Biehler, Klaus; Schwabe, Kay; Haarhaus, Birgit; Quirin, Karl-W; Frank, Uwe; Schempp, Christoph M; Wölfle, Ute

MDPI AG

Chemistry; Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics

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