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Porous silicon-based aptasensors: The next generation of label-free devices for health monitoring

Molecules, ISSN: 1420-3049, Vol: 24, Issue: 12
2019
  • 25
    Citations
  • 0
    Usage
  • 48
    Captures
  • 0
    Mentions
  • 26
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    25
  • Captures
    48
  • Social Media
    26
    • Shares, Likes & Comments
      26
      • Facebook
        26

Review Description

Aptamers are artificial nucleic acid ligands identified and obtained from combinatorial libraries of synthetic nucleic acids through the in vitro process SELEX (systematic evolution of ligands by exponential enrichment). Aptamers are able to bind an ample range of non-nucleic acid targets with great specificity and affinity. Devices based on aptamers as bio-recognition elements open up a new generation of biosensors called aptasensors. This review focuses on some recent achievements in the design of advanced label-free optical aptasensors using porous silicon (PSi) as a transducer surface for the detection of pathogenic microorganisms and diagnostic molecules with high sensitivity, reliability and low limit of detection (LoD).

Bibliographic Details

Terracciano, Monica; Rea, Ilaria; Borbone, Nicola; Moretta, Rosalba; Oliviero, Giorgia; Piccialli, Gennaro; De Stefano, Luca

MDPI AG

Chemistry; Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics

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