Amidoximes and oximes: Synthesis, structure, and their key role as No donors
Molecules, ISSN: 1420-3049, Vol: 24, Issue: 13
2019
- 56Citations
- 100Captures
- 1Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations56
- Citation Indexes56
- 56
- CrossRef47
- Captures100
- Readers100
- 100
- Mentions1
- Blog Mentions1
- 1
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Molecules, Vol. 24, Pages 2470: Amidoximes and Oximes: Synthesis, Structure, and Their Key Role as NO Donors
Molecules, Vol. 24, Pages 2470: Amidoximes and Oximes: Synthesis, Structure, and Their Key Role as NO Donors Molecules doi: 10.3390/molecules24132470 Authors: Tanya Sahyoun Axelle Arrault
Article Description
Nitric oxide (NO) is naturally synthesized in the human body and presents many beneficial biological effects; in particular on the cardiovascular system. Recently; many researchers tried to develop external sources to increase the NO level in the body; for example by using amidoximes and oximes which can be oxidized in vivo and release NO. In this review; the classical methods and most recent advances for the synthesis of both amidoximes and oximes are presented first. The isomers of amidoximes and oximes and their stabilities will also be described; (Z)-amidoximes and (Z)-oximes being usually the most energetically favorable isomers. This manuscript details also the biomimetic and biological pathways involved in the oxidation of amidoximes and oximes. The key role played by cytochrome P450 or other dihydronicotinamide-adenine dinucleotide phosphate (NADPH)-dependent reductase pathways is demonstrated. Finally, amidoximes and oximes exhibit important effects on the relaxation of both aortic and tracheal rings alongside with other effects as the decrease of the arterial pressure and of the thrombi formation
Bibliographic Details
MDPI AG
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