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Catalytic Performance of Immobilized Sulfuric Acid on Silica Gel for N-Formylation of Amines with Triethyl Orthoformate

Molecules, ISSN: 1420-3049, Vol: 27, Issue: 13
2022
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Article Description

In the search for convenient, green, and practical catalytic methods for the current interest in organic synthesis, a simple, green, and highly efficient protocol for N-formylation of various amines was carried out in the presence of immobilized sulfuric acid on silica gel (HSO–SiO ). All reactions were performed in refluxing triethyl orthoformate (65C). The product formamides were obtained with high-to-excellent yields within 4 min to 2 h. The current approach is advantageous, due to its short reaction time and high yields. The catalyst is recyclable with no significant loss in catalytic efficiency.

Bibliographic Details

Salami, Sodeeq Aderotimi; Siwe-Noundou, Xavier; Krause, Rui W M

MDPI AG

Chemistry; Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics

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