Effects of Valproic Acid Embryonic Exposure on Zebrafish: A Systematic Review and Meta-Analysis.
NeuroSci, ISSN: 2673-4087, Vol: 5, Issue: 4, Page: 650-665
2024
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Studies from University Veracruzana Have Provided New Data on Neuroscience (Effects of Valproic Acid Embryonic Exposure on Zebrafish: A Systematic Review and Meta-Analysis)
2024 DEC 25 (NewsRx) -- By a News Reporter-Staff News Editor at Pain & Central Nervous System Daily News -- New study results on neuroscience
Review Description
Exposure to valproic acid (VPA) during embryogenesis has become a valuable tool for modeling neurodevelopmental disorders in animal models such as zebrafish (). This article examines the effects of embryonic exposure to VPA in zebrafish on the basis of 39 articles sourced from PubMed and Google Scholar. We conducted a systematic review and meta-analysis to elucidate the common impacts of VPA exposure and reported that VPA significantly altered development at various levels. Behaviorally, zebrafish exposed to VPA exhibit notable changes in their social interaction patterns. Physiologically, VPA exposure leads to significant alterations, including decreased heart rates, increased mortality rates, and pronounced morphological abnormalities. Pharmacological exposure has been linked to neuroanatomical and neurochemical changes. At the genetic level, VPA exposure is associated with the differential expression of genes involved in neurodevelopment and neuronal function. The synthesized data from these studies underscore the utility of zebrafish as a model organism for investigating the effects of teratogen exposure on neurodevelopment.
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