Nobiletin Inhibits Hypoxia-Induced Placental Damage via Modulating P53 Signaling Pathway
Nutrients, ISSN: 2072-6643, Vol: 14, Issue: 11
2022
- 6Citations
- 12Captures
- 1Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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- Citations6
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- Captures12
- Readers12
- 12
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Nutrients, Vol. 14, Pages 2332: Nobiletin Inhibits Hypoxia-Induced Placental Damage via Modulating P53 Signaling Pathway
Nutrients, Vol. 14, Pages 2332: Nobiletin Inhibits Hypoxia-Induced Placental Damage via Modulating P53 Signaling Pathway Nutrients doi: 10.3390/nu14112332 Authors: Meng-ling Zhang Qian Yang Yan-di Zhu
Article Description
In this study, we aimed to evaluate the effect of Nobiletin (NOB) on the placenta of Spra-gue–Dawley (SD) rats that had undergone reduced uterine perfusion pressure (RUPP) surgery and to evaluate the safety of NOB intervention during pregnancy. The results showed that NOB alleviated placental hypoxia, attenuated placental cell apoptosis, and inhibited placental damage in RUPP rats. No side effect of NOB intervention during pregnancy was observed. BeWo cell lines with P53 knockdown were then constructed using lentiviral transfection, and the P53 signaling pathway was found to be essential for NOB to reduce hypoxia-induced apoptosis of the BeWo cell lines. In summary, NOB attenuated hypoxia-induced placental damage by regulating the P53 signaling pathway, and those findings may contribute some insights into the role of NOB in placental development and the prevention of placental-related diseases.
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