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Effects of Cinnamon (Cinnamomum zeylanicum) Extract on Adipocyte Differentiation in 3T3-L1 Cells and Lipid Accumulation in Mice Fed a High-Fat Diet

Nutrients, ISSN: 2072-6643, Vol: 15, Issue: 24
2023
  • 8
    Citations
  • 0
    Usage
  • 32
    Captures
  • 5
    Mentions
  • 9
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    8
  • Captures
    32
  • Mentions
    5
    • News Mentions
      5
      • News
        5
  • Social Media
    9
    • Shares, Likes & Comments
      9
      • Facebook
        9

Most Recent News

Cinnamon extract shows promise in tackling obesity

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Article Description

Flavonoids and phenolic acid are two of the rich polyphenols found in cinnamon (Cinnamomum zeylanicum). The effects of cinnamon extract on the inhibition of adipocyte differentiation in 3T3-L1 fibroblast cells and prohibitory lipid accumulation in male mice fed a high-fat diet were examined. Upon treating 3T3-L1 cells with cinnamon for 3 days, the cinnamon inhibited lipid accumulation and increased gene expression levels, such as those of adiponectin and leptin. In in vivo experiments, mice were randomized into four groups after a one-week acclimation period, as follows: normal diet, normal diet + 1% cinnamon extract, high-fat diet, and high-fat diet + 1% cinnamon extract. After 14 weeks of supplementation, we found that cinnamon extract increased the expression of lipolysis-related proteins, such as AMPK, p-ACC, and CPT-1, and reduced the expression of lipid-synthesis-related proteins, such as SREBP-1c and FAS, in liver tissue. Our results show that cinnamon extract may exhibit anti-obesity effects via the inhibition of lipid synthesis and adipogenesis and the induction of lipolysis in both 3T3-L1 fibroblast cells and mice fed a high-fat diet. Accordingly, cinnamon extract may have potential anti-obesity effects.

Bibliographic Details

Oh, Joohee; Ahn, SongHee; Zhou, Xiangqin; Lim, Yu Jin; Hong, Sookyeong; Kim, Hyun-Sook

MDPI AG

Agricultural and Biological Sciences; Nursing

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