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The effects of myo-inositol and B and D vitamin supplementation in the db/+ mouse model of gestational diabetes mellitus

Nutrients, ISSN: 2072-6643, Vol: 9, Issue: 2
2017
  • 23
    Citations
  • 0
    Usage
  • 103
    Captures
  • 0
    Mentions
  • 97
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    23
  • Captures
    103
  • Social Media
    97
    • Shares, Likes & Comments
      97
      • Facebook
        97

Article Description

Gestational diabetes mellitus (GDM) is a growing concern, affecting an increasing number of pregnant women worldwide. By predisposing both the affected mothers and children to future disease, GDM contributes to an intergenerational cycle of obesity and diabetes. In order to stop this cycle, safe and effective treatments for GDM are required. This study sought to determine the treatment effects of dietary supplementation with myo-inositol (MI) and vitamins B2, B6, B12, and D in a mouse model of GDM (pregnant db/+ dams). In addition, the individual effects of vitamin B2 were examined. Suboptimal B2 increased body weight and fat deposition, decreased GLUT4 adipose tissue expression, and increased expression of inflammatory markers. MI supplementation reduced weight and fat deposition, and reduced expression of inflammatory markers in adipose tissue of mice on suboptimal B2. MI also significantly reduced the hyperleptinemia observed in db/+ mice, when combined with supplemented B2. MI was generally associated with adipose tissue markers of improved insulin sensitivity and glucose uptake, while the combination of vitamins B2, B6, B12, and D was associated with a reduction in adipose inflammatory marker expression. These results suggest that supplementation with MI and vitamin B2 could be beneficial for the treatment/prevention of GDM.

Bibliographic Details

Plows, Jasmine F; Budin, Florence; Andersson, Rebecka A M; Mills, Valerie J; Mace, Katherine; Davidge, Sandra T; Vickers, Mark H; Baker, Philip N; Silva-Zolezzi, Irma; Stanley, Joanna L

MDPI AG

Agricultural and Biological Sciences; Nursing

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