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Correlation between the Biodistribution of Bovine Leukemia Virus in the Organs and the Proviral Load in the Peripheral Blood during Early Stages of Experimentally Infected Cattle

Pathogens, ISSN: 2076-0817, Vol: 12, Issue: 1
2023
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Researchers from Hokkaido Research Organization Publish Research in Bovine Leukemia Virus (Correlation between the Biodistribution of Bovine Leukemia Virus in the Organs and the Proviral Load in the Peripheral Blood during Early Stages of ...)

2023 FEB 08 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx Life Science Daily -- Fresh data on bovine leukemia virus are presented

Article Description

Bovine leukemia virus (BLV) is the etiological agent of enzootic bovine leukosis. However, the propagation and distribution of BLV after primary infection still need to be fully elucidated. Here, we experimentally infected seven cattle with BLV and analyzed the BLV proviral load (PVL) in the blood and various organs. BLV was first detected in the blood of the cattle after one week, and the blood PVL increased for three weeks after infection. The PVL was maintained at a high level in five cattle, while it decreased to a low or medium level in two cattle. BLV was distributed in various organs, such as the heart, lung, liver, kidney, abomasum, and thymus, and, notably, in the spleen and lymph nodes. In cattle with a high blood PVL, BLV was detected in organs other than the spleen and lymph nodes, whereas in those with a low blood PVL, BLV was only detected in the spleen and lymph nodes. The amount of BLV in the organs was comparable to that in the blood. Our findings point to the possibility of estimating the distribution of BLV provirus in organs, lymph nodes, and body fluids by measuring the blood PVL, as it was positively correlated with the biodistribution of BLV provirus in the body of BLV infection during early stages.

Bibliographic Details

Kohara, Junko; Bai, Lanlan; Takeshima, Shin-Nosuke; Matsumoto, Yuki; Hirai, Tsunao; Aida, Yoko

MDPI AG

Medicine; Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology

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