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Glioblastoma multiforme therapy and mechanisms of resistance

Pharmaceuticals, ISSN: 1424-8247, Vol: 6, Issue: 12, Page: 1475-1506
2013
  • 189
    Citations
  • 148
    Usage
  • 304
    Captures
  • 1
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

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Most Recent News

Why glioblastoma tumors like John McCain’s are so aggressive

Sen. John McCain, R-Ariz., has been diagnosed with a brain cancer known as a glioblastoma. The tumor was discovered when McCain’s doctors removed a blood clot from above his left eye, which speaks to how the disease may have formed in the first place. (More on that later.) Though it’s is rare overall, with 12,000 new cases expected this year, glioblastoma is the most lethal type of brain cancer. G

Review Description

Glioblastoma multiforme (GBM) is a grade IV brain tumor characterized by a heterogeneous population of cells that are highly infiltrative, angiogenic and resistant to chemotherapy. The current standard of care, comprised of surgical resection followed by radiation and the chemotherapeutic agent temozolomide, only provides patients with a 12-14 month survival period post-diagnosis. Long-term survival for GBM patients remains uncommon as cells with intrinsic or acquired resistance to treatment repopulate the tumor. In this review we will describe the mechanisms of resistance, and how they may be overcome to improve the survival of GBM patients by implementing novel chemotherapy drugs, new drug combinations and new approaches relating to DNA damage, angiogenesis and autophagy. © 2013 by the authors; licensee MDPI, Basel, Switzerland.

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