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Silica nanoparticles in transmucosal drug delivery

Pharmaceutics, ISSN: 1999-4923, Vol: 12, Issue: 8, Page: 1-25
2020
  • 48
    Citations
  • 0
    Usage
  • 121
    Captures
  • 2
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    48
  • Captures
    121
  • Mentions
    2
    • Blog Mentions
      1
      • Blog
        1
    • References
      1
      • Wikipedia
        1

Most Recent Blog

Pharmaceutics, Vol. 12, Pages 751: Silica Nanoparticles in Transmucosal Drug Delivery

Pharmaceutics, Vol. 12, Pages 751: Silica Nanoparticles in Transmucosal Drug Delivery Pharmaceutics doi: 10.3390/pharmaceutics12080751 Authors: Twana Mohammed M. Ways Keng Wooi Ng Wing Man Lau

Review Description

Transmucosal drug delivery includes the administration of drugs via various mucous membranes, such as gastrointestinal, nasal, ocular, and vaginal mucosa. The use of nanoparticles in transmucosal drug delivery has several advantages, including the protection of drugs against the harsh environment of the mucosal lumens and surfaces, increased drug residence time, and enhanced drug absorption. Due to their relatively simple synthetic methods for preparation, safety profile, and possibilities of surface functionalisation, silica nanoparticles are highly promising for transmucosal drug delivery. This review provides a description of silica nanoparticles and outlines the preparation methods for various core and surface-functionalised silica nanoparticles. The relationship between the functionalities of silica nanoparticles and their interactions with various mucous membranes are critically analysed. Applications of silica nanoparticles in transmucosal drug delivery are also discussed.

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