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In Vivo Quantification of the Effectiveness of Topical Low-Dose Photodynamic Therapy in Wound Healing Using Two-Photon Microscopy

Pharmaceutics, ISSN: 1999-4923, Vol: 14, Issue: 2
2022
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Article Description

The effect of low-dose photodynamic therapy on in vivo wound healing with topical application of 5-aminolevulinic acid and methylene blue was investigated using an animal model for two laser radiation doses (1 and 4 J/cm). A second-harmonic-generation-to-auto-fluorescence aging index of the dermis (SAAID) was analyzed by two-photon microscopy. SAAID measured at 60–80 µm depths was shown to be a suitable quantitative parameter to monitor wound healing. A comparison of SAAID in healthy and wound tissues during phototherapy showed that both light doses were effective for wound healing; however, healing was better at a dose of 4 J/cm.

Bibliographic Details

Zuhayri, Hala; Nikolaev, Viktor V; Knyazkova, Anastasia I; Lepekhina, Tatiana B; Krivova, Natalya A; Tuchin, Valery V; Kistenev, Yury V

MDPI AG

Pharmacology, Toxicology and Pharmaceutics

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