Complexation: An Interesting Pathway for Combining Two APIs at the Solid State
Pharmaceutics, ISSN: 1999-4923, Vol: 14, Issue: 9
2022
- 4Citations
- 5Captures
- 1Mentions
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Pharmaceutics, Vol. 14, Pages 1960: Complexation: An Interesting Pathway for Combining Two APIs at the Solid State
Pharmaceutics, Vol. 14, Pages 1960: Complexation: An Interesting Pathway for Combining Two APIs at the Solid State Pharmaceutics doi: 10.3390/pharmaceutics14091960 Authors: Fucheng Leng Oleksii Shemchuk
Article Description
Combining different drugs into a single crystal form is one of the current challenges in crystal engineering, with the number of reported multi-drug solid forms remaining limited. This paper builds upon an efficient approach to combining Active Pharmaceutical Ingredients (APIs) containing carboxylic groups in their structure with APIs containing pyridine moieties. By transforming the former into their zinc salts, they can be successfully combined with the pyridine-containing APIs. This work highlights the successfulness of this approach, as well as the improvement in the physical properties of the obtained solid forms.
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MDPI AG
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