Influence of Roll Speed during Roll Compaction and Its Effect on the Prediction of Ribbon Solid Fraction
Pharmaceutics, ISSN: 1999-4923, Vol: 14, Issue: 11
2022
- 4Citations
- 15Captures
- 1Mentions
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Most Recent News
Study Results from Heinrich-Heine-University Update Understanding of Pharmaceutics (Influence of Roll Speed during Roll Compaction and Its Effect on the Prediction of Ribbon Solid Fraction)
2022 NOV 28 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx Drug Daily -- Investigators publish new report on pharmaceutics. According to news
Article Description
Influence of the roll speed (RS) during roll compaction on ribbon, granule, tablet properties and its effect on the prediction of the ribbon solid fraction at-gap is often neglected or controversially discussed. The aim of this study was to investigate the effect of the RS systematically. Microcrystalline cellulose (MCC) and lactose were compressed at several maximum roll pressures ((Formula presented.)) and RS combinations using a gap-controlled roll compactor. The ribbon solid fraction after elastic recovery ((Formula presented.)), granule size distribution and tabletability of the granules as well as the ribbon solid fraction at-gap (Formula presented.) were measured. The Midoux number (Mi), derived from the Johanson model, was used to predict the ribbon solid fraction at-gap (Formula presented.)). The measured (Formula presented.) and the predicted (Formula presented.) lead to a prediction accuracy (PA) of the Midoux number. The results are highly dependent on the material used and the applied (Formula presented.). Higher plasticity of the material leads to a reduction in (Formula presented.) and granule size with increasing RS. However, this effect can be overcome or reduced by adjusting (Formula presented.) above the yield pressure of the used material. These results allow for higher roll speeds as a potential upscaling method in roll compaction. On the other side, the PA of the Midoux number was also reduced with increased RS for MCC and had no effect for lactose. Thus, RS seems to be an important factor in the prediction of roll compaction processes and prediction models should include RS as a parameter to improve their accuracy.
Bibliographic Details
MDPI AG
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