Determination of pro-inflammatory and humoral factors in gonarthrosis in women with hypertension and overweight

Purpose of the study. The purpose of the work, to study the influence of pro-inflammatory cytokines and neurohumoral factors of adipose tissue on the pathogenesis of HA in women with NM and hypertension to further improve the effectiveness of treatment of this group of patients. Materials and methods. We examined 198 women with GA and GA in combination with GC and NM aged 40 to 70 years (average - 62,6 ± 1,9 years) with a disease duration of an average of 13,4 ± 3,8 years. In order to analyze the impact of comorbidpathology on the underlying disease, all surveyed women were divided into three groups. The first group (Gl) included 59 women with symptoms of HA without concomitant pathology, the second (G2) group - 74 women with HA and GC, and the third (G3) 65 women with HA and GC and NM. All patients underwent standard general clinical examination. In order to study the neurohumoral aspects of the disease, enzyme-linked immunosorbent assay of C-reactive protein, tumor necrosis factor, interleukin-1beta, interleukin 6, interleukin 10 and leptin was performed. Results. It was found that the combination of excess weight with the course of HA leads to a more significant increase in the production of proinflammatory cytokines compared with patients with HA without concomitant pathology (p < 0,05). Direct correlations have been established between weight gain and increased levels of proinflammatory cytokines and adipose tissue neurohumoral factors. Conclusions. The combination of inflammatory and destructive changes in the joints in HA with weight gain and increased blood pressure, creates conditions for the development of severe immunological disorders in patients and requires pharmacological correction.