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Intravenous Insulin Infusion Rate and Its Impact on the Time to Resolution of Diabetic Ketoacidosis

Innovative Medicine of Kuban, ISSN: 2541-9897, Vol: 9, Issue: 2, Page: 34-41
2024
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New Diabetic Ketoacidosis Research Reported from Stavropol State Medical University (Intravenous Insulin Infusion Rate and Its Impact on the Time to Resolution of Diabetic Ketoacidosis)

2024 MAY 20 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Trials Daily -- Researchers detail new data in diabetic ketoacidosis. According to

Article Description

Background: Diabetic ketoacidosis (DKA) is an acute and severe complication of type 1 diabetes that is highly prevalent in children and adolescents. Intravenous (IV) insulin infusion is the mainstay of DKA treatment in the intensive care unit; however, standard-dose (0.1 U/kg/h) insulin infusion increases the risk of cerebral edema. Objective: To compare the efficacy and safety of low-dose (0.05 U/kg/h) vs high-dose (0.1 U/kg/h) IV insulin infusion in children and adolescents treated for DKA. Materials and methods: Our randomized single-blind study included 86 patients aged 5 to 14 years urgently hospitalized with symptoms of DKA. Group 1 comprised 40 children who received IV insulin at the low rate (0.05 U/kg/h), whereas group 2 included 46 children who received IV insulin at the standard rate (0.1 U/kg/h). During the treatment we compared the time to DKA resolution and blood glucose level decrease to 15 mmol/L and recorded cases of hypoglycemia, hypokalemia, and papilledema. The Mann-Whitney test was used to determine whether differences were statistically significant. Results: There was no difference between groups 1 and 2 in DKA treatment duration. The blood glucose level was found to decline to 15 mmol/L more slowly in children who received IV insulin at 0.05 U/kg/h. Hypoglycemia, hypokalemia, and papilledema were more common in the standard-dose (0.1 U/kg/h) group. Conclusions: The low-dose IV insulin infusion (0.05 U/kg/h) is safer in terms of complications (cerebral edema) associated with pediatric DKA treatment in the intensive care unit and not inferior to the standard recommended dose (0.1 U/kg/h) in efficacy.

Bibliographic Details

Yuri V. Bykov; Alexander N. Obedin; Alla A. Muravyova; Oleg V. Zinchenko

Scientific Research Institute - Ochapovsky Regional Clinical Hospital No 1

Medicine

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