The vagus nerve: current concepts in anaesthesia and ICU management
Southern African Journal of Anaesthesia and Analgesia, ISSN: 2220-1181, Vol: 28, Issue: 5, Page: 193-197
2022
- 1Citations
- 35Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Review Description
The vagus nerve (XN) is a major component of the autonomic nervous system. It plays an important role both in the regulation of metabolic homeostasis and in inflammatory modulation. XN tone is dampened in stress conditions (either of inflammatory and/ or infectious origin) and the preservation of parasympathetic function may serve as a biomarker of general health, longevity and vitality. COVID-19 remains a major healthcare issue worldwide. Excessive inflammation and its end organ consequences are key elements in the pathogenesis of COVID-19-induced multiple organ dysfunction, as well as post-COVID-19 syndrome (long COVID). XN stimulation has been hypothesised to control both the SARS-CoV-2 replication and the ensuing inflammation, and could improve the clinical outcomes as an adjunct treatment. Electrical stimulation of the auricular XN (AXNS) is an emerging technology, with few side effects and anaesthetic implications, and is showing promise with respect to the management of gastroparesis, epilepsy, migraine, autoimmune diseases, anxiety and major depressive disorders, obesity, SARS-CoV-2 infection in the intensive care unit (ICU), and long COVID. Continuous vagal tone monitoring in patients with COVID-19 may potentially also be used as a predictive marker of the COVID-19 illness course, and an evaluation of future therapies.
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