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Clinical Appearance and Diagnosis of Heparin Induced Thrombocytopenia

Journal of Biomedical Research & Environmental Sciences, Page: 466-471
2021
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Article Description

Heparin-İnduced Thrombocytopenia (HIT) [1] is caused by an autoantibody directed against endogenous Platelet Factor 4 (PF4) in complex with heparin. This antibody activates platelets and can cause arterial and venous thrombosis. Although the mortality rate of untreated HIT is determined as 20 percent; With early diagnosis and treatment, mortality rates have been reported to be less than 2 percent [2,3]. The clinical picture and diagnosis of HIT will be discussed here. The management of HIT and the use of heparin and alternative anticoagulants are discussed separately.

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