MicroRNA-141 inhibits the self-renewal of glioblastoma stem cells via Jaggedl
Molecular Medicine Reports, ISSN: 1791-3004, Vol: 16, Issue: 1, Page: 167-173
2017
- 17Citations
- 16Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations17
- Citation Indexes17
- 17
- CrossRef16
- Captures16
- Readers16
- 16
Article Description
Glioblastoma multiforme is one of the most lethal types of brain cancer. With limited success from conventional therapies, the cancer stem cell theory was developed, and investigation into microRNAs (miRs) has facilitated understanding of this theory. The present study demonstrated that miR-141 is suppressed in sorted cluster of differentiation (CD) 133(+) glioblastoma stem cells (GSCs) compared with CD133(-) non-glioblastoma stem cells (NSCs) from patient samples. In addition, miR-141 overexpression inhibited the sphere formation ability of GSCs in vitro and in vivo. Furthermore, Jagged1 may reverse the effect of miR-141; miR-141 was revealed to target the 3′-untranslated region of Jagged1, thereby inhibiting the stemness of GSCs. Thus, miR-141 may serve as a potent antioncomir targeting cancer stem cells, and may facilitate the development of therapeutic targets to prolong the overall survival of patients with glioblastoma.
Bibliographic Details
Spandidos Publications
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