Low‑dose venetoclax combined with azacitidine in older and frail patients with newly diagnosed acute myeloid leukaemia
Oncology Letters, ISSN: 1792-1082, Vol: 27, Issue: 5, Page: 228
2024
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Most Recent News
Research Data from Department of Hematopathology Update Understanding of Acute Myeloid Leukemia (Low-dose Venetoclax Combined With Azacitidine In Older and Frail Patients With Newly Diagnosed Acute Myeloid Leukaemia)
2024 MAY 07 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx Hematology Daily -- Investigators publish new report on Oncology - Acute Myeloid
Article Description
In the present study, the aim was to evaluate the clinical efficacy and safety of low‑dose venetoclax combined with azacitidine for the treatment of older and frail patients with newly diagnosed acute myeloid leukaemia (AML). Data of 26 older patients with newly diagnosed AML admitted to Yuyao People's Hospital (Yuyao, China) between January 2021 and May 2023 were retrospectively analysed. The treatment regimens were as follows: Subcutaneous injection of 100 mg azacitidine on days 1‑5 and 100 mg oral venetoclax on days 3‑16 or 200 mg oral venetoclax on days 3‑30. The median age of the 26 patients was 73 years. After the first course of treatment, the complete remission (CR) and CR with incomplete haema‑ tological recovery rate was 84.6%, and the objective response rate was 96.2%. The most common adverse events noted during treatment were haematological adverse events including grade 3/4 granulocytosis (57.7%), febrile neutropenia (30.8%), pulmo‑ nary infection (32.0%), thrombocytopenia (42.3%) and anaemia (42.3%). A total of 13 (50.0%) patients did not require platelet (PLT) infusion during treatment. The main non‑haematological adverse reactions included gastrointestinal reactions such as nausea, vomiting and diarrhoea. Patients were followed up until December 2023, with a median follow‑up time of 9.5 months (range, 1.9‑26.0 months). Of the 26 patients, nine (34.6%) patients experienced relapse, with a mean recurrence time of 5.9 months. In conclusion, preliminary results indicated that low‑dose vene‑ toclax combined with azacitidine is effective and safe for the treatment of older and frail patients with newly diagnosed AML, providing a new treatment option for these patients.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85189024283&origin=inward; http://dx.doi.org/10.3892/ol.2024.14362; http://www.ncbi.nlm.nih.gov/pubmed/38586209; http://www.spandidos-publications.com/10.3892/ol.2024.14362; https://dx.doi.org/10.3892/ol.2024.14362; https://www.spandidos-publications.com/10.3892/ol.2024.14362
Spandidos Publications
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