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How common is vitamin B-12 deficiency? 2

The American Journal of Clinical Nutrition, ISSN: 0002-9165, Vol: 89, Issue: 2, Page: 693S-696S
2009
  • 488
    Citations
  • 0
    Usage
  • 627
    Captures
  • 28
    Mentions
  • 1
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    488
    • Citation Indexes
      479
    • Policy Citations
      8
      • Policy Citation
        8
    • Clinical Citations
      1
      • PubMed Guidelines
        1
  • Captures
    627
  • Mentions
    28
    • News Mentions
      23
      • News
        23
    • Blog Mentions
      5
      • Blog
        5
  • Social Media
    1
    • Shares, Likes & Comments
      1
      • Facebook
        1

Most Recent News

Vitamin deficiency may be why you’re so tired Vitamin deficiency may be why you’re so tired

Share This article was originally featured on The Conversation. Feeling drained and lethargic is common: A 2022 national survey found that 13.5% of U.S. adults

Article Description

In considering the vitamin B-12 fortification of flour, it is important to know who is at risk of vitamin B-12 deficiency and whether those individuals would benefit from flour fortification. This article reviews current knowledge of the prevalence and causes of vitamin B-12 deficiency and considers whether fortification would improve the status of deficient subgroups of the population. In large surveys in the United States and the United Kingdom, ≈6% of those aged ≥60 y are vitamin B-12 deficient (plasma vitamin B-12 < 148 pmol/L), with the prevalence of deficiency increasing with age. Closer to 20% have marginal status (plasma vitamin B-12: 148–221 pmol/L) in later life. In developing countries, deficiency is much more common, starting in early life and persisting across the life span. Inadequate intake, due to low consumption of animal-source foods, is the main cause of low serum vitamin B-12 in younger adults and likely the main cause in poor populations worldwide; in most studies, serum vitamin B-12 concentration is correlated with intake of this vitamin. In older persons, food-bound cobalamin malabsorption becomes the predominant cause of deficiency, at least in part due to gastric atrophy, but it is likely that most elderly can absorb the vitamin from fortified food. Fortification of flour with vitamin B-12 is likely to improve the status of most persons with low stores of this vitamin. However, intervention studies are still needed to assess efficacy and functional benefits of increasing intake of the amounts likely to be consumed in flour, including in elderly persons with varying degrees of gastric atrophy.

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