The Green Algal Carotenoid Siphonaxanthin Inhibits Adipogenesis in 3T3-L1 Preadipocytes and the Accumulation of Lipids in White Adipose Tissue of KK-Ay Mice 1–3
The Journal of Nutrition, ISSN: 0022-3166, Vol: 145, Issue: 3, Page: 490-498
2015
- 46Citations
- 55Captures
- 3Mentions
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Metrics Details
- Citations46
- Citation Indexes46
- 46
- CrossRef41
- Captures55
- Readers55
- 55
- Mentions3
- News Mentions3
- 3
Most Recent News
Carotenoid from green algae shows ‘potent’ anti-fat activity
A carotenoid from green algae called siphonaxanthin may inhibit the development of fat cells and the build-up of fat in fat tissue, suggests new research
Article Description
Background: Siphonaxanthin, a xanthophyll present in green algae, has been shown to possess antiangiogenic and apoptosis-inducing activities. Objective: We evaluated the antiobesity effects of siphonaxanthin by using a 3T3-L1 cell culture system and in diabetic KK-Ay mice. Methods: 3T3-L1 cells were differentiated with or without 5 μmol/L siphonaxanthin, and lipid accumulation and critical gene expressions for adipogenesis were examined. In vivo, 4-wk-old male KK-Ay mice were administered daily oral treatment of 1.3 mg siphonaxanthin for 6 wk and body weight, visceral fat weight, serum variables, and gene expressions involved in lipid metabolism were evaluated. Results: Compared with the other carotenoids evaluated, siphonaxanthin potently inhibited adipocyte differentiation. Siphonaxanthin significantly suppressed lipid accumulation at noncytotoxic concentrations of 2.5 and 5 μmol/L by 29% and 43%, respectively. The effects of siphonaxanthin were largely limited to the early stages of adipogenesis. Siphonaxanthin significantly inhibited protein kinase B phosphorylation by 48% and 72% at 90 and 120 min, respectively. The expressions of key adipogenesis genes, including CCAAT/enhancer binding protein α ( Cebpa ), peroxisome proliferator activated receptor γ ( Pparg ), fatty acid binding protein 4 ( Fabp4 ), and stearoyl coenzyme A desaturase 1 ( Scd1 ), were elevated by 1.6- to 166-fold during adipogenesis. After 8 d of adipocyte differentiation, siphonaxanthin significantly lowered gene expression of Cebpa, Pparg, Fabp4, and Scd1 by 94%, 83%, 95%, and 90%, respectively. Moreover, oral administration of siphonaxanthin to KK-Ay mice significantly reduced the total weight of white adipose tissue (WAT) by 13%, especially the mesenteric WAT by 28%. Furthermore, siphonaxanthin administration reduced lipogenesis and enhanced fatty acid oxidation in adipose tissue. Siphonaxanthin was observed to highly accumulate in mesenteric WAT, and the accumulation in the mesenteric WAT was almost 2- and 3-fold that in epididymal ( P = 0.14) and perirenal ( P < 0.05) WAT, respectively. Conclusion: These results provide evidence that siphonaxanthin may effectively regulate adipogenesis in 3T3-L1 cells and diabetic KK-Ay mice.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0022316622086515; http://dx.doi.org/10.3945/jn.114.200931; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84928386317&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/25733464; https://linkinghub.elsevier.com/retrieve/pii/S0022316622086515; https://dx.doi.org/10.3945/jn.114.200931; http://jn.nutrition.org/lookup/doi/10.3945/jn.114.200931; https://academic.oup.com/jn/article-pdf/145/3/490/30060333/490.pdf; https://academic.oup.com/jn/article/145/3/490/4743690; http://jn.nutrition.org/content/145/3/490.short?rss=1; http://jn.nutrition.org/content/145/3/490; http://jn.nutrition.org/cgi/doi/10.3945/jn.114.200931
Elsevier BV
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