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Free ig light chains interact with sphingomyelin and are found on the surface of myeloma plasma cells in an aggregated form

Journal of Immunology, ISSN: 0022-1767, Vol: 185, Issue: 7, Page: 4179-4188
2010
  • 21
    Citations
  • 0
    Usage
  • 16
    Captures
  • 1
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    21
  • Captures
    16
  • Mentions
    1
    • References
      1
      • Wikipedia
        1

Article Description

Free κ L chains (FκLCs) are expressed on the surface of myeloma cells and are being assessed as a therapeutic target for the treatment of multiple myeloma. Despite its clinical potential, the mechanism by which FκLCs interact with membranes remains unresolved. In this study, we show that FκLCs associate with sphingomyelin on the plasma membrane of myeloma cells. Moreover, membrane-bound FκLCs are aggregated, suggesting that aggregation is required for intercalation with membranes. Finally, we propose a model where the binding of FκLCs with sphingomyelin on secretory vesicle membranes is stabilized by self-aggregation, with aggregated FκLCs exposed on the plasma membrane after exocytosis. Although it is well known that protein aggregates bind membranes, this is only the second example of an aggregate being found on the surface of cells that also secrete the protein in its native form. We postulate that many other aggregation-prone proteins may associate with cell membranes by similar mechanisms. Copyright© 2010 by The American Association of Immunologists, Inc.

Bibliographic Details

Hutchinson, Andrew T; Ramsland, Paul A; Jones, Darren R; Agostino, Mark; Lund, Maria E; Jennings, Cameron V; Bockhorni, Vanessa; Yuriev, Elizabeth; Edmundson, Allen B; Raison, Robert L

Oxford University Press (OUP)

Medicine; Immunology and Microbiology

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