Type III IFNs in pteropid bats: Differential expression patterns provide evidence for distinct roles in antiviral immunity
Journal of Immunology, ISSN: 0022-1767, Vol: 186, Issue: 5, Page: 3138-3147
2011
- 90Citations
- 130Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations90
- Citation Indexes90
- CrossRef90
- 85
- Captures130
- Readers130
- 130
Article Description
Bats are known to harbor a number of emerging and re-emerging zoonotic viruses, many of which are highly pathogenic in other mammals but result in no clinical symptoms in bats. The ability of bats to coexist with viruses may be the result of rapid control of viral replication early in the immune response. IFNs provide the first line of defense against viral infection in vertebrates. Type III IFNs (IFN-λs) are a recently identified IFN family that share similar antiviral activities with type I IFNs. To our knowledge, we demonstrate the first functional analysis of type III IFNs from any species of bat, with the investigation of two IFN-λ genes from the pteropid bat, Pteropus alecto. Our results demonstrate that bat type III IFN has similar antiviral activity to type I and III IFNs from other mammals. In addition, the two bat type III IFNs are differentially induced relative to each other and to type I IFNs after treatment or transfection with synthetic dsRNA. Infection with the bat paramyxovirus, Tioman virus, resulted in no upregulation of type I IFN production in bat splenocytes but was capable of inducing a type III IFN response in three of the four bats tested. To our knowledge, this is the first report to describe the simultaneous suppression of type I IFN and induction of type III IFN after virus infection. These results may have important implications for the role of type III IFNs in the ability of bats to coexist with viruses. Copyright © 2011 by The American Association of Immunologists, Inc.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79952755976&origin=inward; http://dx.doi.org/10.4049/jimmunol.1003115; http://www.ncbi.nlm.nih.gov/pubmed/21278349; https://journals.aai.org/jimmunol/article/186/5/3138/768/Type-III-IFNs-in-Pteropid-Bats-Differential; https://dx.doi.org/10.4049/jimmunol.1003115
Oxford University Press (OUP)
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