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Anti-MUC1 antibodies react directly with MUC1 peptides presented by class I H2 and HLA molecules

Journal of Immunology, ISSN: 0022-1767, Vol: 161, Issue: 2, Page: 767-775
1998
  • 44
    Citations
  • 0
    Usage
  • 12
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    44
    • Citation Indexes
      44
  • Captures
    12

Article Description

Peptides bound in the groove of MHC class I molecules and detected by CTLs are not normally accessible to Ab. We now report that MUC1 peptides that are bound within the groove of MHC class I molecules (H2 and HLA) and that can be detected by CTLs can also be detected by anti-MUC1 Abs. mAbs to the middle and C-terminal regions of the class I-associated peptides but not to the N terminus were able to react with MUC1 peptides bound to H2K and HLA- A*0201, and only to the mid-region for H2D, by flow cytometry and also to block CTL activity. Molecular modeling showed that the N terminus is buried (and not accessible), whereas the midpeptide residues form a loop and the C terminus is free, making these two regions accessible to Ab. The findings demonstrate for the first time that peptides associated with class I molecules can be detected by anti-peptide Abs.

Bibliographic Details

Vasso Apostolopoulos; Gareth Chelvanayagam; Pei-Xiang Xing; Ian F. C. McKenzie

Oxford University Press (OUP)

Medicine; Immunology and Microbiology

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