PlumX Metrics
Embed PlumX Metrics

Cutting edge: The immunostimulatory activity of the lung surfactant protein-A involves Toll-like receptor 4

Journal of Immunology, ISSN: 0022-1767, Vol: 168, Issue: 12, Page: 5989-5992
2002
  • 279
    Citations
  • 0
    Usage
  • 103
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Article Description

The collectin surfactant protein-A (SP-A) is involved in the innate host defense and the regulation of inflammatory processes in the lung. In this work we investigated the molecular mechanisms related to the immunostimulatory activity of SP-A using macrophages from C3H/HeJ mice, which carry an inactivating mutation in the Toll-like receptor (TLR)4 gene, and TLR4-transfected Chinese hamster ovary cells. We demonstrate that SP-A-induced activation of the NF-κB signaling pathway and up-regulation of cytokine synthesis such as TNF-α and IL-10 are critically dependent on the TLR4 functional complex. These findings support the concept that TLR4 is a pattern recognition receptor that signals in response to both foreign pathogens and endogenous host mediators.

Bibliographic Details

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know