Cutting edge: The immunostimulatory activity of the lung surfactant protein-A involves Toll-like receptor 4
Journal of Immunology, ISSN: 0022-1767, Vol: 168, Issue: 12, Page: 5989-5992
2002
- 279Citations
- 103Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations279
- Citation Indexes279
- 279
- CrossRef241
- Captures103
- Readers103
- 103
Article Description
The collectin surfactant protein-A (SP-A) is involved in the innate host defense and the regulation of inflammatory processes in the lung. In this work we investigated the molecular mechanisms related to the immunostimulatory activity of SP-A using macrophages from C3H/HeJ mice, which carry an inactivating mutation in the Toll-like receptor (TLR)4 gene, and TLR4-transfected Chinese hamster ovary cells. We demonstrate that SP-A-induced activation of the NF-κB signaling pathway and up-regulation of cytokine synthesis such as TNF-α and IL-10 are critically dependent on the TLR4 functional complex. These findings support the concept that TLR4 is a pattern recognition receptor that signals in response to both foreign pathogens and endogenous host mediators.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0037097672&origin=inward; http://dx.doi.org/10.4049/jimmunol.168.12.5989; http://www.ncbi.nlm.nih.gov/pubmed/12055204; https://journals.aai.org/jimmunol/article/168/12/5989/33628/Cutting-Edge-The-Immunostimulatory-Activity-of-the; https://dx.doi.org/10.4049/jimmunol.168.12.5989
Oxford University Press (OUP)
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