Functional role of C-terminal sequence elements in the transporter associated with antigen processing
Journal of Immunology, ISSN: 0022-1767, Vol: 174, Issue: 1, Page: 328-339
2005
- 15Citations
- 3Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations15
- Citation Indexes15
- 15
- CrossRef13
- Captures3
- Readers3
Article Description
TAP delivers antigenic peptides into the endoplasmic reticulum (ER) that are subsequently bound by MHC class I molecules. TAP consists of two subunits (TAP1 and TAP2), each with a transmembrane (TMD) and a nucleotide-binding (NBD) domain. The two TAP-NBDs have distinct biochemical properties and control different steps during the peptide translocation process. We noted previously that the nonhomologous C-terminal tails of rat TAP1 and TAP2 determine the distinct functions of TAP-NBD1 and -NBD2. To identify the sequence elements responsible for the asymmetrical NBD function, we constructed chimeric rat TAP variants in which we systematically exchanged sequence regions of different length between the two TAP-NBDs. Our fine-mapping studies demonstrate that a nonhomologous region containing the α6/β10-loop in conjunction with the downstream switch region is directly responsible for the functional separation of the TAP-NBDs. The α6/β10-loop determines the nonsynonymous nucleotide binding of NBD1 and NBD2, whereas the switch region seems to play a critical role in regulating the functional cross-talk between the structural domains of TAP. Based on our findings, we postulate that these two sequence elements build a minimal functional unit that controls the asymmetry of the two TAP-NBDs.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=10844255719&origin=inward; http://dx.doi.org/10.4049/jimmunol.174.1.328; http://www.ncbi.nlm.nih.gov/pubmed/15611256; https://journals.aai.org/jimmunol/article/174/1/328/72279/Functional-Role-of-C-Terminal-Sequence-Elements-in; https://dx.doi.org/10.4049/jimmunol.174.1.328; https://www.jimmunol.org/content/174/1/328
Oxford University Press (OUP)
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