PlumX Metrics
Embed PlumX Metrics

Cutting edge: Tlr5 mice are more susceptible to Escherichia coli urinary tract infection

Journal of Immunology, ISSN: 0022-1767, Vol: 178, Issue: 8, Page: 4717-4720
2007
  • 162
    Citations
  • 0
    Usage
  • 99
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Article Description

Although TLR5 regulates the innate immune response to bacterial flagellin, it is unclear whether its function is essential during in vivo murine infections. To examine this question, we challenged Tlr5 mice transurethrally with Escherichia coli. At 2 days postinfection, wild-type mice exhibited increased inflammation of the bladder in comparison to Tlr5 mice. By day 5 postinfection, Tlr5 mice had significantly more bacteria in the bladders and kidneys in comparison to wild-type mice and showed increased inflammation in both organs. In addition, flagellin induced high levels of cytokine and chemokine expression in the bladder that was dependent on TLR5. Together, these data represent the first evidence that TLR5 regulates the innate immune response in the urinary tract and is essential for an effective murine in vivo immune response to an extracellular pathogen. Copyright © 2007 by The American Association of Immunologists, Inc.

Bibliographic Details

Andersen-Nissen, Erica; Hawn, Thomas R.; Smith, Kelly D.; Nachman, Alex; Lampano, Aaron E.; Uematsu, Satoshi; Akira, Shizuo; Aderem, Alan

The American Association of Immunologists

Medicine; Immunology and Microbiology

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know