Cutting edge: Tlr5 mice are more susceptible to Escherichia coli urinary tract infection
Journal of Immunology, ISSN: 0022-1767, Vol: 178, Issue: 8, Page: 4717-4720
2007
- 162Citations
- 99Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations162
- Citation Indexes162
- 162
- CrossRef141
- Captures99
- Readers99
- 99
Article Description
Although TLR5 regulates the innate immune response to bacterial flagellin, it is unclear whether its function is essential during in vivo murine infections. To examine this question, we challenged Tlr5 mice transurethrally with Escherichia coli. At 2 days postinfection, wild-type mice exhibited increased inflammation of the bladder in comparison to Tlr5 mice. By day 5 postinfection, Tlr5 mice had significantly more bacteria in the bladders and kidneys in comparison to wild-type mice and showed increased inflammation in both organs. In addition, flagellin induced high levels of cytokine and chemokine expression in the bladder that was dependent on TLR5. Together, these data represent the first evidence that TLR5 regulates the innate immune response in the urinary tract and is essential for an effective murine in vivo immune response to an extracellular pathogen. Copyright © 2007 by The American Association of Immunologists, Inc.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=34247105910&origin=inward; http://dx.doi.org/10.4049/jimmunol.178.8.4717; http://www.ncbi.nlm.nih.gov/pubmed/17404249; https://journals.aai.org/jimmunol/article/178/8/4717/74457/Cutting-Edge-Tlr5-Mice-Are-More-Susceptible-to; https://dx.doi.org/10.4049/jimmunol.178.8.4717
The American Association of Immunologists
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